Publication

業績

国嶋崇隆　教授

  1. Effects of the (Trialkyl)ammonium Structures in (Ammonio)amidyl Groups on π-Electron Donating Ability and Thermal Stability: Experimental and Computational Study
    Hikaru Fujita, Takanari Arai, Hiroki Muraya, Yoshika Matsuyama, Munetaka Kunishima, Chemical and Pharmaceutical Bulletin. Aug 29, 2025. https://doi.org/10.1248/cpb.c25-00260
  2. Development of a Triazinyluronium-Based Dehydrative Condensing Reagent with No Heteroatomic Bonds
    Gaku Mizushima, Hikaru Fujita, Munetaka Kunishima. The Journal of Organic Chemistry. Dec 20, 2024. https://doi.org/10.1021/acs.joc.4c02075  
  3. Alkoxy Exchange Strategy for the Synthesis of N,N′-Dimethylated (Alkoxy)triazinediones as Solid Reagents for Acid-Catalyzed O-Alkylation
    Hikaru Fujita, Tomomi Yagitani, Munetaka Kunishima. The Journal of Organic Chemistry. Oct 1, 2024. https://doi.org/10.1021/acs.joc.4c01406  
  4. Bicyclic-Ammonium-Incorporated Ylidic Nitrogen Groups for Strong π-Electron Donation in Push–Pull Benzene π-Conjugated Systems
    Hikaru Fujita, Takanari Arai, Naoto Kuchiki, Munetaka Kunishima. Organic Letters. Aug 26, 2024. https://doi.org/10.1021/acs.orglett.4c02378  
  5. Phototriggered Generation of Ynol Ethers and Their Rearrangement to Ketenes.
    Shunsuke Mogami, Masanobu Baba, Taniyuki Furuyama, Munetaka Kunishima, Kenji Mishiro. The Journal of organic chemistry. Jul 16, 2024. https://doi.org/10.1021/acs.joc.4c00947
  6. Development of a Purely Isolable (Dimorpholino)triazine-Based Reagent for the Epoxidation of Alkenes
    Hikaru Fujita, Toshiyuki Kato, Tatsuki Betsuyaku, Munetaka Kunishima. Synlett. 2024年6月28日. https://doi.org/10.1055/a-2356-8451  
  7. Development of radioiodine-labeled mequitazine for evaluation of hepatic CYP2D activity
    Asuka Mizutani, Masato Kobayashi, Kodai Nishi, Ken-ichi Fujita, Kotaro Takahashi, Yuka Muranaka, Kakeru Sato, Masanori Kitamura, Chie Suzuki, Ryuichi Nishii… Frontiers in Pharmacology. 15, Jun 19, 2024.  https://doi.org/10.3389/fphar.2024.1397288
  8. Carbocationoids, a concept for controlling highly reactive cationic species
    Hikaru Fujita, Daichi Shimada, Jotaro Kudo, Kazuyuki Kosha, Satoshi Kakuyama, Hiromitsu Terasaki, Munetaka Kunishima. Communications Chemistry. 7(1), Mar 13, 2024. https://doi.org/10.1038/s42004-024-01139-w  
  9. Drug–drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers
    Hikaru Fujita, Sachiko Arai, Hiroshi Arakawa, Kana Hamamoto, Toshiyuki Kato, Tsubasa Arai, Nanaka Nitta, Kazuki Hotta, Natsuko Hosokawa, Takako Ohbayashi… Bioorganic & Medicinal Chemistry. 102 117674-117674, Mar, 2024. https://doi.org/10.1016/j.bmc.2024.117674
  10. Phototriggered Butenolide Formation from a Cyclobutenedione and an Acidic Nucleophile.
    Kenji Mishiro, Aiko Sesumi, Takanori Fujii, Taniyuki Furuyama, Munetaka Kunishima. Organic letters. 26(1) 380-384, Jan 12, 2024. https://doi.org/10.1021/acs.orglett.3c04054
  11. Epitope-Based Specific Antibody Modifications.
    Saki Horie, Kenji Mishiro, Mio Nishino, Inori Domae, Mitsuo Wakasugi, Tsukasa Matsunaga, Munetaka Kunishima. Bioconjugate chemistry. 34(11) 2022-2033, Nov 15, 2023. https://doi.org/10.1021/acs.bioconjchem.3c00340
  12. Synthesis and characterization of tetraphenylammonium salts
    Hikaru Fujita, Ozora Sasamoto, Shiori Kobayashi, Masanori Kitamura, Munetaka Kunishima. Nature Communications. 13(1), Dec, 2022. https://doi.org/10.1038/s41467-022-30282-y
  13. Hydrophobic‐Substrate‐Selective Dehydrative Condensations at the Emulsion Interface under Conditions where Competitive Reactions Proceed in the Bulk Aqueous Phase
    Takuya Matsumoto, Eri Hirata, Hanlin Zhang, Kazuhito Hioki, Munetaka Kunishima. Asian Journal of Organic Chemistry. Nov 14, 2022. https://doi.org/10.1002/ajoc.202200602 https://doi.org/10.1002/ajoc.202200602
  14. Measurement of Hepatic CYP3A4 and 2D6 Activity Using Radioiodine-Labeled O-Desmethylvenlafaxine.
    Asuka Mizutani, Masato Kobayashi, Riku Aibe, Yuka Muranaka, Kodai Nishi, Masanori Kitamura, Chie Suzuki, Ryuichi Nishii, Naoto Shikano, Yasuhiro Magata …International journal of molecular sciences. 23(19), Sep 28, 2022. https://doi.org/10.3390/ijms231911458
  15. Ideal Thesis Research and Clinical Training as Pharmaceutical Practice in 6-year Pharmaceutical Education and Study System
    Munetaka Kunishima. YAKUGAKU ZASSHI. 142(8) 821-827, Aug 1, 2022. https://doi.org/10.1248/yakushi.22-00004-3
  16. Discovery of a Novel Aminocyclopropenone Compound That Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal Cancer Growth
    Kondo, H., Mishiro, K., Iwashima, Y., Qiu, Y., Kobayashi, A., Lim, K., Domoto, T., Minamoto, T., Ogawa, K., Kunishima, M… Cells. 11(3) 317-317, (2022). https://doi.org/10.3390/cells11030317
  17. Synthesis of N-Aminated Salts of Aliphatic tert-Amines, (Trialkyl)amidines, and (Pentaalkyl)guanidines by Electrophilic Amination in an Ethereal Solvent
    Fujita, H., Arai, T., Kunishima, M. Chemical and Pharmaceutical Bulletin. 70(1) 85-88, (2022). https://doi.org/10.1248/cpb.c21-00673
  18. Nucleophilic substitution reactions of unbranched alkyl amines using triazine reagents
    Kitamura, M., Kitaoka, Y., Fujita, H., Kunishima, M. Tetrahedron Letters. 93 153692-153692, (2022). https://doi.org/10.1016/j.tetlet.2022.153692
  19. 2,4,6‐Tris( p ‐methoxybenzyloxy)‐1,3,5‐triazine (TriBOT‐PM)
    Hikaru Fujita, Munetaka KunishimaEncyclopedia of Reagents for Organic Synthesis. 1-3, May 17, 2021. https://doi.org/10.1002/047084289x.rn02381
  20. N-Acyltriazinedione; a Novel Acylating Reagent Synthesized from a Triazinone-Type Condensing Reagent
    Kohei Yamada, Jeongsu Lee, Mika Kota, Yukiko Karuo, Masanori Kitamura, Munetaka Kunishima. Chemical and Pharmaceutical Bulletin. 69(5) 498-502, May 1, 2021.  https://doi.org/10.1248/cpb.c20-00952
  21. Efficiency Enhancement of a Photocatalytic Decarbonylation of an Aminocyclopropenone by Benzothiophene Substitution.
    Kenji Mishiro, Mitsuki Nomura, Taniyuki Furuyama, Munetaka Kunishima. The Journal of organic chemistry. 86(4) 3625-3636, Feb 19, 2021. https://doi.org/10.1021/acs.joc.0c02997
  22. Conjugation of 4-(dimethylamino)pyridine to primary amines in aqueous buffer solutions using an N-hydroxysuccinimide ester reagent
    Horie, S., Fujita, H., Yamashita, R., Kunishima, M. Tetrahedron Letters. 81, (2021).  https://doi.org/10.1016/j.tetlet.2021.153343
  23. Development of a triazinedione-based dehydrative condensing reagent containing 4-(dimethylamino)pyridine as an acyl transfer catalyst
    Jie Liu, Hikaru Fujita, Masanori Kitamura, Daichi Shimada, Munetaka Kunishima. Organic & Biomolecular Chemistry. 19(21) 4712-4719, 2021. https://doi.org/10.1039/d1ob00450f
  24. A versatile iodo(iii)etherification of terminal ethynylsilanes using BF3–OiPr2 and alkyl benzyl ethers
    Takuya Matsumoto, Hiroshi Hagiyama, Kanetsugu Kuribayashi, Kazuhito Hioki, Hikaru Fujita, Masahito Ochiai, Munetaka Kunishima. Organic & Biomolecular Chemistry. (2021)  https://doi.org/10.1039/d1ob00479d
  25. 6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients.
    Yusuke Masuo, Ken-Ichi Fujita, Kenji Mishiro, Natsumi Seba, Tatsuya Kogi, Hidenori Okumura, Natsumi Matsumoto, Munetaka Kunishima, Yukio Kato. Drug metabolism and pharmacokinetics. 35(6) 555-562, Dec, 2020.  https://doi.org/10.1016/j.dmpk.2020.09.001
  26. Trizaine-based dehydrative condensation reagents bearing carbon-substituents
    Masanori Kitamura, Sayaka Komine, Kohei Yamada, Munetaka Kunishima. Tetrahedron. 76(12) 130900-130900, Mar, 2020. https://doi.org/10.1016/j.tet.2019.130900
  27. Development of Hydrophilic Polyacrylamide Gel-Based Condensing Reagents Comprised of Chlorotriazine.
    Kohei Yamada, Shota Hirozawa, Junqing Xia, Munetaka Kunishima. Chemical & pharmaceutical bulletin. 68(6) 534-537, 2020.  https://doi.org/10.1248/cpb.c20-00074
  28. Development of Triazinone-Based Condensing Reagents for Amide Formation
    Kohei Yamada, Mika Kota, Kensuke Takahashi, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima. The Journal of Organic Chemistry. 84(23) 15042-15051, Dec 6, 2019. https://doi.org/10.1021/acs.joc.9b01261
  29. Preparation of Alkyl Ethers with Diallyltriazinedione-Type Alkylating Agents (ATTACKs-R) Under Acid Catalysis
    Fujita Hikaru, Yamashita Rina, Fujii Takanori, Yamada Kohei, Kitamura Masanori, Kunishima Munetaka. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. (27) 4436-4446, Jul 23, 2019. https://doi.org/10.1002/ejoc.201900607
  30. Substitution of the Dimethylamino Group in Gramines and One-Pot Cyclization to Tetrahydro-beta-carbolines Using a Triazine-Based Activating Agent
    Fujita Hikaru, Nishikawa Riho, Sasamoto Ozora, Kitamura Masanori, Kunishima Munetaka. JOURNAL OF ORGANIC CHEMISTRY. 84(13) 8380-8391, Jul 5, 2019.  https://doi.org/10.1021/acs.joc.9b00039
  31. Substitution of the Dimethylamino Group in Gramines and One-Pot Cyclization to Tetrahydro-β-carbolines Using a Triazine-Based Activating Agent.
    Fujita H, Nishikawa R, Sasamoto O, Kitamura M, Kunishima M. The Journal of organic chemistry. 84(13) 8380-8391, Jul 5, 2019. https://doi.org/10.1021/acs.joc.9b00039
  32. Phototriggered Active Alkyne Generation from Cyclopropenones with Visible Light-Responsive Photocatalysts.
    Mishiro K, Kimura T, Furuyama T, Kunishima M. Organic letters. 21(11) 4101-4105, Jun 7, 2019. https://doi.org/10.1021/acs.orglett.9b01280
  33. Development of a Storable Triazinone-Based Reagent for O-p-Methoxybenzylation under Mild Heating Conditions
    Fujita Hikaru, Terasaki Hiromitsu, Kakuyama Satoshi, Hioki Kazuhito, Kunishima Munetaka. ORGANIC LETTERS. 21(9) 3093-3097, May 3, 2019. https://doi.org/10.1021/acs.orglett.9b00732
  34. Development of a Storable Triazinone-Based Reagent for O- p-Methoxybenzylation under Mild Heating Conditions.
    Fujita H, Terasaki H, Kakuyama S, Hioki K, Kunishima M. Organic letters. 21(9) 3093-3097, May 3, 2019. https://doi.org/10.1021/acs.orglett.9b00732
  35. Phototriggered Active Alkyne Generation from Cyclopropenones with Visible Light-Responsive Photocatalysts.
    Kenji Mishiro, Takeshi Kimura, Taniyuki Furuyama, Munetaka Kunishima. Organic letters. 21(11) 4101-4105, May, 2019. https://doi.org/10.1021/acs.orglett.9b01280
  36. Triazine-Based Cationic Leaving Group: Synergistic Driving Forces for Rapid Formation of Carbocation Species
    Fujita Hikaru, Kakuyama Satoshi, Fukuyoshi Shuichi, Hayakawa Naoko, Oda Akifumi, Kunishima Munetaka. Journal of Organic Chemistry. 83(8) 4568-4580, 2018. https://doi.org/10.1021/acs.joc.8b00331
  37. Development of radioiodine labeled acetaminophen for specific, high-contrast imaging of malignant melanoma
    Zhu Wen Jing, Kobayashi Masato, Yamada Kohei, Nishi Kodai, Takahashi Kotaro, Mizutani Asuka, Nishii Ryuichi, Flores Leo G. II, Shikano Naoto, Kunishima Munetaka… Nuclear Medicine and Biology. 59 16-21, 2018. https://doi.org/10.1016/j.nucmedbio.2017.12.008
  38. An Isolable and Bench-Stable Epoxidizing Reagent Based on Triazine: Triazox
    Yamada Kohei, Igarashi Yuki, Betsuyaku Tatsuki, Kitamura Masanori, Hirata Koki, Hioki Kazuhito, Kunishima Munetaka. Organic Letters. 20(7) 2015-2019, 2018. https://doi.org/10.1021/acs.orglett.8b00560
  39. Development of Triazine-Based Benzylating Reagents Possessing t-Butyl Group on the Triazine Core: Thermally Controllable Reagents for the Initiation of Reaction
    Karuo Yukiko, Yamada Kohei, Kunishima Munetaka. Chemical & Pharmaceutical Bulletin. 66(3) 303-308, 2018. https://doi.org/10.1248/cpb.c17-00897
  40. Development of highly electron-deficient and less sterically-hindered phosphine ligands possessing 1,3,5-triazinyl groups
    Abe Kazumi, Kitamura Masanori, Fujita Hikaru, Kunishima Munetaka. Molecular Catalysis. 445 87-93, 2018.  https://doi.org/10.1016/j.mcat.2017.11.008
  41. Cooperation of the Neutral and the Cationic Leaving Group Pathways in Acid-Catalyzed O-Benzylation of TriBOT.
    Fujita H, Hayakawa N, Kunishima M. The Journal of organic chemistry. 83(17) 10684-10687, 2018. https://doi.org/10.1021/acs.joc.8b01505
  42. Development of triazine-based esterifying reagents containing pyridines as a nucleophilic catalyst.
    Yamada K, Liu J, Kunishima M. Organic & biomolecular chemistry. 16(35) 6569-6575, 2018. https://doi.org/10.1039/c8ob01660g
  43. Phototriggered Ketone Formation from an Aminocyclopropenone and a Carboxylic Acid.
    Mishiro K, Yushima Y, Kunishima M. The Journal of organic chemistry. 83(21) 13595-13603, 2018. https://doi.org/10.1021/acs.joc.8b02250
  44. Combination Metabolomics Approach for Identifying Endogenous Substrates of Carnitine/Organic Cation Transporter OCTN1.
    Masuo Y, Ohba Y, Yamada K, Al-Shammari AH, Seba N, Nakamichi N, Ogihara T, Kunishima M, Kato Y. Pharmaceutical research. 35(11) 224-224, 2018. https://doi.org/10.1007/s11095-018-2507-1
  45. Imido-substituted triazines as dehydrative condensing reagents for the chemoselective formation of amides in the presence of free hydroxy groups
    Kitamura Masanori, Sasaki Suguru, Nishikawa Riho, Yamada Kohei, Kunishima Munetaka. RSC Advances. 8(40) 22482-22489, 2018. https://doi.org/10.1039/c8ra03057j
  46. Study of O-Allylation Using Triazine-Based Reagents
    Yamada Kohei, Hayakawa Naoko, Fujita Hikaru, Kitamura Masanori, Kunishima Munetaka. Chemical & Pharmaceutical Bulletin. 65(1) 112-115, 2017. https://doi.org/10.1248/cpb.c16-00744
  47. Phototriggered Dehydration Condensation Using an Aminocyclopropenone
    Mishiro Kenji, Yushima Yuki, Kunishima Munetaka. Organic Letters. 19(18) 4912-4915, 2017. https://doi.org/10.1021/acs.orglett.7b02383
  48. Novel Alkylating Reagents Designed by the Characteristics of 1,3,5-Triazines
    Kunishima Munetaka, Yamada Kohei, Fujita Hikaru, Kitamura Masanori. Journal of Synthetic Organic Chemistry Japan. 75(10) 1023-1034, 2017. https://doi.org/10.5059/yukigoseikyokaishi.75.1023
  49. N,N ‘-Dimethylated Benzyloxytriazinedione: A Stable Solid Reagent for Acid-Catalyzed O-Benzylation
    Fujita Hikaru, Kakuyama Satoshi, Kunishima Munetaka. European Journal of Organic Chemistry.  (4) 833-839, 2017. https://doi.org/10.1002/ejoc.201601387
  50. Development of a method for the synthesis of 2,4,5-trisubstituted oxazoles composed of carboxylic acid, amino acid, and boronic acid
    Yamada Kohei, Kamimura Naoto, Kunishima Munetaka. Beilstein Journal of Organic Chemistry. 13 1478-1485, 2017. https://doi.org/10.3762/bjoc.13.146
  51. Chemo-enzymatic synthesis of a glycosylated peptide containing a complex N-glycan based on unprotected oligosaccharides by using DMT-MM and Endo-M
    Tomabechi Yusuke, Katoh Toshihiko, Kunishima Munetaka, Inazu Toshiyuki, Yamamoto Kenji. Glycoconjugate Journal. 34(4) 481-487, 2017. https://doi.org/10.1007/s10719-017-9770-y
  52. トリアジンの特性を活用した新規アルキル化剤
    75(10) 1023-1034, 2017. https://doi.org/10.5059/yukigoseikyokaishi.75.1023
  53. Potent triazine-based dehydrocondensing reagents substituted by an amido group
    Kunishima Munetaka, Kato Daiki, Kimura Nobu, Kitamura Masanori, Yamada Kohei, Hioki Kazuhito. Beilstein Journal of Organic Chemistry. 12 1897-1903, 2016. https://doi.org/10.3762/bjoc.12.179
  54. Mild Amide-Cleavage Reaction Mediated by Electrophilic Benzylation
    Yamada Kohei, Karuo Yukiko, Tsukada Yuichi, Kunishima MunetakaChemistry-a European Journal 22(39) 14042-14047, 2016. https://doi.org/10.1002/chem.201603120
  55. Increased Plasma Concentrations of Unbound SN-38, the Active Metabolite of Irinotecan, in Cancer Patients with Severe Renal Failure
    Fujita Ken-ichi, Masuo Yusuke, Okumura Hidenori, Watanabe Yusuke, Suzuki Hiromichi, Sunakawa Yu, Shimada Ken, Kawara Kaori, Akiyama Yuko, Kitamura Masanori… Pharmaceutical Research. 33(2) 269-282, 2016. https://doi.org/10.1007/s11095-015-1785-0
  56. Development of acid-catalyzed fluorous benzylating reagents based on a triazinedione core
    Kunishima Munetaka, Asao Ryohei, Yamada Kohei, Kitamura Masanori, Fujita Hikaru. Journal of Fluorine Chemistry. 190 68-74, 2016. https://doi.org/10.1016/j.jfluchem.2016.09.003
  57. Development of a Triazine-Based tert-Butylating Reagent, TriAT-tBu
    Yamada Kohei, Hayakawa Naoko, Fujita Hikaru, Kitamura Masanori, Kunishima Munetaka. European Journal of Organic Chemistry. (23) 4093-4098, 2016. https://doi.org/10.1002/ejoc.201600663
  58. Alcohol- and Amine-Tolerant Synthesis of Six-Membered Cyclic Quaternary Ammonium Salts by Using a Triazine-Based Reagent
    Kitamura Masanori, Yamamura Seina, Yamada Kohei, Kunishima Munetaka. Asian Journal of Organic Chemistry. 5(12) 1508-1517, 2016. https://doi.org/10.1002/ajoc.201600429
  59. 125I標識CYP代謝基質誘導体を用いたイメージングによるCYP活性定量法の確立
    水谷明日香, 水谷明日香, 高須啓彰, 外間つづみ, 西井龍一, 鈴木千恵, 小林正和, 北村正典, 国嶋崇隆, 間賀田泰寛 …核医学(Web) 53(Supplement) 1250(J‐STAGE), 2016. https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201802288918260584
  60. Study of the Reactivities of Acid-Catalyzed O-Benzylating Reagents Based on Structural Isomers of 1,3,5-Triazine
    Fujita Hikaru, Hayakawa Naoko, Kunishima Munetaka. Journal of Organic Chemistry. 80(21) 11200-11205, 2015. https://doi.org/10.1021/acs.joc.5b02059
  61. O-Benzylation of Carboxylic Acids Using 2,4,6-Tris(benzyloxy)-1,3,5-triazine (TriBOT) under Acidic or Thermal Conditions
    Yamada Kohei, Yoshida Saki, Fujita Hikaru, Kitamura Masanori, Kunishima Munetaka. European Journal of Organic Chemistry. (36) 7997-8002, 2015. https://doi.org/10.1002/ejoc.201501172
  62. Synthesis of Pyrrolidinium Salts Using a Triazine-based Reagent under Mild Conditions
    Kitamura Masanori, Yamamura Seina, Kobayashi Hiroko, Yamamoto Mariko, Tada Kayo, Hioki Kazuhito, Yamada Kohei, Kunishima Munetaka. Chemistry Letters. 43(10) 1593-1595, 2014. https://doi.org/10.1246/cl.140503
  63. Specific Labeling of Streptavidin for Better Understanding of Ligand Modification in Modular Method for Affinity Labeling (MoAL)
    Kunishima Munetaka, Kato Daiki, Nakanishi Shuichi, Kitamura Masanori, Yamada Kohei, Terao Keiji, Asano Tomoya. Chemical & Pharmaceutical Bulletin. 62(11) 1146-1150, 2014. https://doi.org/10.1248/cpb.c14-00468
  64. Role of Linkers in Tertiary Amines That Mediate or Catalyze 1,3,5-Triazine-Based Amide-Forming Reactions
    Kitamura Masanori, Kawasaki Fumitaka, Ogawa Kouichi, Nakanishi Shuichi, Tanaka Hiroyuki, Yamada Kohei, Kunishima Munetaka. Journal of Organic Chemistry. 79(8) 3709-3714, 2014. https://doi.org/10.1021/jo500376m
  65. Development of a New Benzylating Reagent Spontaneously Releasing Benzyl Cation Equivalents at Room Temperature
    Yamada Kohei, Tsukada Yuichi, Karuo Yukiko, Kitamura Masanori, Kunishima Munetaka. Chemistry-a European Journal. 20(38) 12274-12278, 2014. https://doi.org/10.1002/chem.201403158
  66. 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Chloride
    Masanori Kitamura, Munetaka Kunishima. Encyclopedia of Reagents for Organic Synthesis, May, 2013.
  67. Synthesis and evaluation of iodinated cyclopropanecarboxylic acid {3-[6-(phenylamino)-pyrimidin-4-ylamino]-phenyl}-amides as EGFR-TK imaging agents
    Yoshimoto Mitsuyoshi, Kimura Sadaaki, Yamada Kohei, Hirata Masahiko, Ohmomo Yoshiro, Kunishima Munetaka, Kawai Keiichi, Fujii Hirofumi. Journal of Labelled Compounds & Radiopharmaceuticals. 56 S373, 2013.  https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000318694100374&DestApp=WOS_CPL
  68. Study of 1,3,5-Triazine-Based Catalytic Amide-Forming Reactions: Effect of Solvents and Basicity of Reactants
    Kunishima Munetaka, Kitamura Masanori, Tanaka Hiroyuki, Nakakura Ichiro, Moriya Takahiro, Hioki Kazuhito. Chemical & Pharmaceutical Bulletin. 61(8) 882-886, 2013. https://doi.org/10.1248/cpb.c13-00368
  69. Binding of sulforhodamine B to human serum albumin: A spectroscopic study
    Kitamura Masanori, Murakami Koji, Yamada Kohei, Kawai Keiichi, Kunishima Munetaka. Dyes and Pigments. 99(3) 588-593, 2013. https://doi.org/10.1016/j.dyepig.2013.06.011
  70. A Practical Method for p-Methoxybenzylation of Hydroxy Groups Using 2,4,6-Tris(p-methoxybenzyloxy)-1,3,5-triazine (TriBOT-PM)
    Yamada Kohei, Fujita Hikaru, Kitamura Masanori, Kunishima Munetaka. Synthesis-Stuttgart. 45(21) 2989-2997, 2013. https://doi.org/10.1055/s-0033-1339713
  71. A new method using 2-chloro-4,6-dimethoxy-1,3,5-triazine for facile elimination of dimethylamino group in Eschenmoser’s methylenation for synthesis of alpha,beta-unsaturated esters
    Yamada Kohei, Masaki Kazumasa, Hagimoto Yuri, Kamiya Seina, Kunishima Munetaka. Tetrahedron Letters. 54(13) 1758-1760, 2013. https://doi.org/10.1016/j.tetlet.2013.01.092
  72. Substrate-Selective Dehydrocondensation at the Interface of Micelles and Emulsions of Common Surfactants
    Kunishima Munetaka, Kikuchi Kanako, Kawai Yukio, Hioki Kazuhito. Angewandte Chemie-International Edition 51(9) 2080-2083, 2012. https://doi.org/10.1002/anie.201107706
  73. Study on 1,3,5-Triazine Chemistry in Dehydrocondensation: Gauche Effect on the Generation of Active Triazinylammonium Species
    Kunishima Munetaka, Ujigawa Takae, Nagaoka Yoshie, Kawachi Chiho, Hioki Kazuhito, Shiro Motoo. Chemistry-a European Journal. 18(49) 15856-15867, 2012. https://doi.org/10.1002/chem.201202236
  74. One-Pot Preparation of Oxazol-5(4H)-ones from Amino Acids in Aqueous Solvents
    Fujita Hikaru, Kunishima Munetaka. Chemical & Pharmaceutical Bulletin. 60(7) 907-912, 2012. https://doi.org/10.1248/cpb.c12-00291
  75. N-Isopropyl-p-iodoamphetamine Hydrochloride Is Predominantly Metabolized by CYP2C19
    Fujita Ken-ichi, Sugiyama Minako, Akiyama Yuko, Hioki Kazuhito, Kunishima Munetaka, Nishi Kodai, Kobayashi Masato, Kawai Keiichi, Sasaki Yasutsuna. Drug Metabolism and Disposition. 40(5) 843-846, 2012. https://doi.org/10.1124/dmd.111.043893
  76. N-ISOPROPYL-P-IODOAMPHETAMINE HYDROCHLORIDE (IMP) IS PREDOMINANTLY METABOLIZED BY CYP2C19.
    Fujita K, Sugiyama M, Akiyama Y, Hioki K, Kunishima M, Kobayashi M, Kawai K, Sasaki Y. Clinical Pharmacology & Therapeutics. 91 S16, 2012. https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000300524900040&DestApp=WOS_CPL
  77. A Novel Acid-Catalyzed O-Benzylating Reagent with the Smallest Unit of Imidate Structure
    Yamada Kohei, Fujita Hikaru, Kunishima MunetakaOrganic Letters 14(19) 5026-5029, 2012. https://doi.org/10.1021/ol302222p
  78. New approach to oligotriazoles using a cobalt complex of propargyl azides as a synthetic component
    Tsukada Yuichi, Yamada Kohei, Kunishima MunetakaTetrahedron Letters 52(26) 3358-3360, 2011. https://doi.org/10.1016/j.tetlet.2011.04.082
  79. Labeling study of avidin by modular method for affinity labeling (MoAL)
    Nakanishi Shuichi, Tanaka Hiroyuki, Hioki Kazuhito, Yamada Kohei, Kunishima Munetaka. Bioorganic & Medicinal Chemistry Letters. 20(23) 7050-7053, 2010. https://doi.org/10.1016/j.bmcl.2010.09.109
  80. Effects of stereochemistry and beta-substituents on the rates of vinylic S(N)2 reaction of hypervalent vinyl(phenyl)-lambda(3)-iodanes with tetrabutylammonium halides
    Miyamoto Kazunori, Okubo Takuji, Hirobe Masaya, Kunishima Munetaka, Ochiai Masahito. Tetrahedron. 66(31) 5819-5826, 2010. https://doi.org/10.1016/j.tet.2010.04.041

2010年以前のリストについてはResearchmapを参考にしてください　→

北條恵子　講師

  1. Water-Based Solid-Phase Peptide Synthesis without Hydroxy Side Chain Protection
    Keiko Hojo, Yuki Manabe, Tomoyo Uda, Yuko Tsuda. JOURNAL OF ORGANIC CHEMISTRY. Aug, 2022. https://doi.org/10.1021/acs.joc.2c00828
  2. Environmentally Conscious In-Water Peptide Synthesis Using Boc Strategy
    Keiko Hojo, Suzuko Fujiwara, Hoshito Inai, Yuki Manabe, Yuko Tsuda. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. 28(2), Mar, 2022. https://doi.org/10.1007/s10989-021-10354-1
  3. Exploration of Active Site-Directed Plasmin Inhibitors: Beyond Tranexamic Acid
    Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Yoshio Okada. PROCESSES. 9(2), Feb, 2021. https://doi.org/10.3390/pr9020329
  4. Design of new cyclic plasmin inhibitors
    Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka. JOURNAL OF PEPTIDE SCIENCE. 24 S117-S118, Sep, 2018. https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000447650300188&DestApp=WOS_CPL
  5. Development of a Single-Chain Peptide Agonist of the Relaxin-3 Receptor Using Hydrocarbon Stapling.
    Keiko Hojo, Mohammed Akhter Hossain, Julien Tailhades, Fazel Shabanpoor, Lilian L L Wong, Emma E K Ong-Pålsson, Hanna E Kastman, Sherie Ma, Andrew L Gundlach, K Johan Rosengren… Journal of medicinal chemistry. 59(16) 7445-56, Aug 25, 2016. https://doi.org/10.1021/acs.jmedchem.6b00265
  6. Oligomerization of neutral peptides derived from the JC virus agnoprotein through a cysteine residue
    Koushi Hidaka, Keiko Hojo, Shio Fujioka, Souichi Nukuzuma, Yuko Tsuda. AMINO ACIDS. 47(10) 2205-2213, Oct, 2015. https://doi.org/10.1007/s00726-015-2004-3
  7. Development of a Sortase A-mediated Peptide-labeled Liposome Applicable to Drug-delivery Systems.
    Atsushi Tabata, Yukimasa Ohkubo, Natsuki Anyoji, Keiko Hojo, Toshifumi Tomoyasu, Youhei Tatematsu, Kazuto Ohkura, Hideaki Nagamune. Anticancer research. 35(8) 4411-7, Aug, 2015. https://www.ncbi.nlm.nih.gov/pubmed/26168480
  8. Aqueous microwave-assisted solid-phase peptide synthesis using Fmoc strategy. III: Racemization studies and water-based synthesis of histidine-containing peptides
    Keiko Hojo, Natsuki Shinozaki, Koushi Hidaka, Yuko Tsuda, Yoshinobu Fukumori, Hideki Ichikawa, John D. Wade. AMINO ACIDS. 46(10) 2347-2354, Oct, 2014. https://doi.org/10.1007/s00726-014-1779-y
  9. Aqueous Microwave-Assisted Solid-Phase Peptide Synthesis Using Fmoc Strategy. II. Racemization Studies and Water Based Synthesis of Cysteine-Containing Peptides
    Keiko Hojo, Natsuki Shinozaki, Asaki Hara, Mare Onishi, Yoshinobu Fukumori, Hideki Ichikawa. PROTEIN AND PEPTIDE LETTERS. 20(10) 1122-1128, Oct, 2013. https://www.ncbi.nlm.nih.gov/pubmed/23517723
  10. Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles
    Keiko Hojo, Natsuki Shinozaki, Yoshimi Nozawa, Yoshinobu Fukumori, Hideki Ichikawa. APPLIED SCIENCES. 3(3) 614-623, Sep, 2013. https://doi.org/10.3390/app3030614
  11. Aqueous microwave-assisted solid-phase peptide synthesis using Fmoc strategy: in-water synthesis of “difficult sequences”.
    Keiko Hojo, Hideki Ichikawa, Asaki Hara, Mare Onishi, Koichi Kawasaki, Yoshinobu Fukumori. Protein and peptide letters. 19(11) 1231-6, Nov, 2012. https://doi.org/10.2174/092986612803217114
  12. Development of a method for environmentally friendly chemical peptide synthesis in water using water-dispersible amino acid nanoparticles
    .Keiko Hojo, Asaki Hara, Hiroyuki Kitai, Mare Onishi, Hideki Ichikawa, Yoshinobu Fukumori, Koichi Kawasaki. Chemistry Central journal. 5 49-49, Aug 25, 2011. https://doi.org/10.1186/1752-153X-5-49
  13. Peptide synthesis ‘in water’ by a solution-phase method using water-dispersible nanoparticle Boc-amino acid.
    Keiko Hojo, Hideki Ichikawa, Mare Onishi, Yoshinobu Fukumori, Koichi Kawasaki. Journal of peptide science : an official publication of the European Peptide Society. 17(7) 487-92, Jul, 2011. https://doi.org/10.1002/psc.1367
  14. Facile Synthesis of a Chitosan Hybrid of a Laminin-related Peptide and Its Antimetastatic Effect in Mice
    Keiko Hojo, Mitsuko Maeda, Yu Mu, Haruhiko Kamada, Yasuo Tsutsumi, Yasuhiro Nishiy Ama, Tomoko Yoshikawa, Keisuke Kurita, Lawrence H Block, Tadanori Mayumi… Journal of Pharmacy and Pharmacology. 52(1) 67-73, Feb 18, 2010. https://doi.org/10.1211/0022357001773526

2010年以前のリストについてはResearchmapを参考にしてください　→